Abstract Search

ea0092op-03-02 | Oral Session 3: Signalling in Thyroid cancer | ETA2023

Determination of the role of map kinase and PI3K/AKT signaling pathways in the regulation of multidrug resistance proteins in thyroid cancer

Godlewska Marlena , Ratajczak Maciej , Gajda Ewa , Gawel agata , Zebracka-Gala Jadwiga , Cieślicka Marta , Oczko-Wojciechowska Malgorzata , Kowalska Malgorzata , Gawel Damian

Thyroid cancer (TC) has one of the fastest increasing incidences worldwide and primarily involves papillary thyroid cancer (PTC). Cancer cells have numerous mechanisms that govern drug resistance, among which activation of multidrug resistance (MDR) genes encoding ABC efflux pumps plays an important role. Acquisition of drug resistance by TC cells is becoming a significant obstacle to effective therapy, leading to insensitivity to classical chemotherapeutics, but also to speci...

1 shares

ea0092ps3-28-01 | Translational 2 | ETA2023

Study on the role of podoplanin in papillary thyroid carcinoma using rna sequencing

Gawel Damian , Mielecki Damian , Bętkowska Anna , Rozwadowski Marcin , Gawel Agata M. , Zeber-Lubecka Natalia , Kulecka Maria , Gajda Ewa , Godlewska Marlena

Introduction: Podoplanin (PDPN) is a transmembrane protein linked with metastases of various cancers, including papillary thyroid carcinoma (PTC). PDPN is significantly upregulated in PTC specimens and PTC- derived cell lines: TPC1 and BCPAP, harboring RET/PTC and BRAF V600E alterations, respectively. We observed that depletion of PDPN impairs migration of TPC1 cells, but surprisingly, augments metastases of BCPAP cells. To elucidate this phenomenon we aimed to further investi...

0 shares

Endocrine Abstracts

Determination of the role of map kinase and PI3K/AKT signaling pathways in the regulation of multidrug resistance proteins in thyroid cancer

Study on the role of podoplanin in papillary thyroid carcinoma using rna sequencing

BiosciAbstracts